Delta Air Lines is a major American airline, with its headquarters and largest hub at Hartsfield–Jackson Atlanta International Airport in Atlanta, Georgia.[25] The airline along with its subsidiaries and regional affiliates operate over 5,400 flights daily and serve an extensive domestic and international network that includes 319 destinations in 54 countries on six continents, as of October 2016.[17] Delta is one of the four founding members of the SkyTeam airline alliance, and operates joint ventures with Air France-KLM, Alitalia, Virgin Atlantic, and Virgin Australia.[17] Regional service is operated under the brand name Delta Connection.